CMap Candidate Details

Structure:
CMap ID: C01544
Pert ID: BRD-A64485570
Compound Name: trifluridine
Targets: TYMS
MoA: Thymidylate synthase inhibitor; DNA directed DNA polymerase inhibitor
SMILES: OC[C@H]1OC(C[C@@H]1O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
InchiKey: VSQQQLOSPVPRAZ-GFCOJPQKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90857 BRD-A64485570 MCF10A 10 uM 12 h 0.0 0.0 0.0 0.0 0.0 0.0
96456 BRD-A64485570 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96524 BRD-A64485570 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100265 BRD-A64485570 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.84 0.18
124616 BRD-A64485570 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124725 BRD-A64485570 JURKAT 1.11 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
124762 BRD-A64485570 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
124881 BRD-A64485570 THP1 1.11 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
124916 BRD-A64485570 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132689 BRD-A64485570 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132754 BRD-A64485570 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132789 BRD-A64485570 HELA 0.74 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.16
132810 BRD-A64485570 HT29 0.01 uM 24 h 0.18 0.75 0.0 0.32 1.14 0.87
132916 BRD-A64485570 MDAMB231 0.74 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).