CMap Candidate Details

Structure:
CMap ID: C15448
Pert ID: BRD-K40965114
Compound Name: cyanopindolol
Targets: ADRB1; HTR1A
MoA: Adrenergic receptor antagonist
SMILES: CC(C)(C)NC[C@H](O)COc1cccc2[nH]c(C#N)cc12
InchiKey: QXIUMMLTJVHILT-LBPRGKRZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6746 BRD-K40965114 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7151 BRD-K40965114 A549 10 uM 6 h 0.3 1.23 0.5 -0.26 -0.88 0.26
7316 BRD-K40965114 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.18 -0.6 0.0
7653 BRD-K40965114 HCC515 10 uM 6 h -0.3 -1.25 0.69 -0.29 -0.96 0.44
7862 BRD-K40965114 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8090 BRD-K40965114 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8368 BRD-K40965114 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8814 BRD-K40965114 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99512 BRD-K40965114 U2OS 10 uM 6 h 0.22 0.91 0.03 -0.23 -0.76 0.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).