CMap Candidate Details

Structure:
CMap ID: C15456
Pert ID: BRD-K40990712
Compound Name: hexamethyleneamiloride
Targets: GNRHR; SLC9A1
MoA: Sodium/hydrogen antiport inhibitor
SMILES: NC(=N)NC(=O)c1nc(Cl)c(nc1N)N2CCCCCC2
InchiKey: RQQJJXVETXFINY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4112 BRD-K40990712 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4571 BRD-K40990712 HCC515 10 uM 6 h -0.21 -0.89 0.03 0.0 0.0 0.0
4805 BRD-K40990712 PC3 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.26 1.35
4932 BRD-K40990712 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44394 BRD-K40990712 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44704 BRD-K40990712 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45253 BRD-K40990712 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45523 BRD-K40990712 HT29 10 uM 6 h 0.0 0.0 0.0 -0.17 -0.58 0.0
45822 BRD-K40990712 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46390 BRD-K40990712 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46711 BRD-K40990712 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99513 BRD-K40990712 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).