CMap Candidate Details

Structure:
CMap ID: C15512
Pert ID: BRD-K41185545
Compound Name: ambrisentan
Targets: EDNRA; EDNRB
MoA: Endothelin receptor antagonist
SMILES: COC([C@H](Oc1nc(C)cc(C)n1)C(O)=O)(c1ccccc1)c1ccccc1
InchiKey: OUJTZYPIHDYQMC-LJQANCHMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123342 BRD-K41185545 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
123366 BRD-K41185545 MCF10A 3.33 uM 24 h 0.35 1.47 1.12 0.0 0.0 0.0
123459 BRD-K41185545 THP1 10 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
131527 BRD-K41185545 A375 0.03 uM 24 h -0.32 -1.35 0.98 0.35 1.23 1.19
131553 BRD-K41185545 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131587 BRD-K41185545 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131628 BRD-K41185545 HEK293 0.74 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
131661 BRD-K41185545 HELA 2.22 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
131725 BRD-K41185545 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
131779 BRD-K41185545 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
131858 BRD-K41185545 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131892 BRD-K41185545 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131917 BRD-K41185545 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131954 BRD-K41185545 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).