CMap Candidate Details

Structure:
CMap ID: C15532
Pert ID: BRD-K41260949
Compound Name: valproic-acid
Targets: ABAT; HDAC1; SCN1A; SCN3A; ALDH5A1
MoA: HDAC inhibitor; GABA receptor agonist; GABAergic transmission enhancer; Voltage-gated sodium channel blocker
SMILES: CCCC(CCC)C(O)=O
InchiKey: NIJJYAXOARWZEE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1135 BRD-K41260949 PC3 10 uM 6 h -0.22 -0.92 0.06 -0.33 -1.1 0.86
1463 BRD-K41260949 NPC 625 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9422 BRD-K41260949 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10245 BRD-K41260949 HCC515 10 uM 6 h 0.27 1.12 0.26 0.0 0.0 0.0
10785 BRD-K41260949 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11486 BRD-K41260949 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11765 BRD-K41260949 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12050 BRD-K41260949 NCIH596 10 uM 6 h -0.21 -0.88 0.03 0.0 0.0 0.0
12316 BRD-K41260949 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.37
12790 BRD-K41260949 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12925 BRD-K41260949 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13271 BRD-K41260949 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
51031 BRD-K41260949 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91069 BRD-K41260949 HUH7 25 uM 72 h 0.0 0.0 0.0 -0.24 -0.81 0.13
95338 BRD-K41260949 A549 1.11 uM 6 h 0.0 0.0 0.0 -0.37 -1.23 1.28
99041 BRD-K41260949 NEU 10 uM 6 h 0.21 0.86 0.01 0.29 1.04 0.53
99276 BRD-K41260949 U2OS 20 uM 6 h -0.19 -0.77 0.0 0.0 0.0 0.0
123237 BRD-K41260949 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123313 BRD-K41260949 HELA 3.33 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.02
131588 BRD-K41260949 HA1E 0.74 uM 24 h -0.23 -0.97 0.11 -0.36 -1.23 1.25
131629 BRD-K41260949 HEK293 0.01 uM 24 h -0.28 -1.17 0.48 -0.33 -1.09 0.84
131687 BRD-K41260949 HT29 2.22 uM 24 h 0.3 1.26 0.57 0.0 0.0 0.0
131726 BRD-K41260949 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131780 BRD-K41260949 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
131824 BRD-K41260949 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131859 BRD-K41260949 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131893 BRD-K41260949 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
131955 BRD-K41260949 YAPC 0.74 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.1
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).