CMap Candidate Details

Structure:
CMap ID: C01558
Pert ID: BRD-A64977602
Compound Name: mirtazapine
Targets: ADRA2A; ADRA2B; ADRA2C; HTR2A; HTR2C; HTR3A
MoA: Serotonin receptor antagonist; Adrenergic receptor antagonist
SMILES: CN1CCN2C(C1)c1ccccc1Cc1cccnc21
InchiKey: RONZAEMNMFQXRA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5538 BRD-A64977602 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5852 BRD-A64977602 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25222 BRD-A64977602 PC3 10 uM 6 h 0.19 0.8 0.0 -0.33 -1.12 0.94
25479 BRD-A64977602 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.05 0.71
39582 BRD-A64977602 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40707 BRD-A64977602 NEU 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.14
41007 BRD-A64977602 NPC 10 uM 24 h -0.2 -0.84 0.01 -0.22 -0.74 0.05
41329 BRD-A64977602 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100268 BRD-A64977602 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
124579 BRD-A64977602 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124617 BRD-A64977602 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124660 BRD-A64977602 HELA 0.37 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
124694 BRD-A64977602 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124763 BRD-A64977602 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
124799 BRD-A64977602 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
132690 BRD-A64977602 A549 0.01 uM 24 h 0.0 0.0 0.0 0.21 0.74 0.04
132756 BRD-A64977602 HEK293 0.01 uM 24 h 0.26 1.1 0.24 0.3 1.06 0.61
132835 BRD-A64977602 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132871 BRD-A64977602 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132932 BRD-A64977602 THP1 0.25 uM 24 h 0.25 1.05 0.17 -0.27 -0.9 0.28
132953 BRD-A64977602 YAPC 0.01 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).