CMap Candidate Details

Structure:
CMap ID: C15631
Pert ID: BRD-K41564320
Compound Name: purvalanol-b
Targets: CDK2; CDK4; MAPK1; MAPK3
MoA: Tyrosine kinase inhibitor
SMILES: CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c2ncn(C(C)C)c2n1
InchiKey: ZKDXRFMOHZVXSG-HNNXBMFYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6749 BRD-K41564320 A375 10 uM 24 h -0.24 -1.02 0.18 0.0 0.0 0.0
6995 BRD-K41564320 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7318 BRD-K41564320 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7863 BRD-K41564320 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8172 BRD-K41564320 MCF??7.00 10 uM 6 h 0.24 0.98 0.09 -0.31 -1.04 0.67
8506 BRD-K41564320 PC3 10 uM 6 h 0.0 0.0 0.0 -0.19 -0.64 0.01
8815 BRD-K41564320 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.16 1.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).