CMap Candidate Details

Structure:
CMap ID: C15643
Pert ID: BRD-K41599323
Compound Name: lonafarnib
Targets: FNTA
MoA: Farnesyltransferase inhibitor
SMILES: NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
InchiKey: DHMTURDWPRKSOA-RUZDIDTESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90853 BRD-K41599323 MCF10A 10 uM 12 h 0.0 0.0 0.0 0.0 0.0 0.0
95545 BRD-K41599323 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95633 BRD-K41599323 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123550 BRD-K41599323 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123604 BRD-K41599323 HEK293 0.125 uM 24 h 0.18 0.77 0.0 0.0 0.0 0.0
123669 BRD-K41599323 HT29 10 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.3
123736 BRD-K41599323 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123780 BRD-K41599323 YAPC 10 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
132001 BRD-K41599323 A375 0.74 uM 24 h 0.27 1.13 0.29 -0.32 -1.07 0.75
132052 BRD-K41599323 HELA 0.08 uM 24 h 0.25 1.05 0.18 0.0 0.0 0.0
132127 BRD-K41599323 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).