CMap Candidate Details

Structure:
CMap ID: C15802
Pert ID: BRD-K42125900
Compound Name: docetaxel
Targets: TUBB
MoA: Tubulin inhibitor
SMILES: CC(=O)O[C@]12CO[C@@H]1C[C@H](O)[C@]1(C)[C@@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c3ccccc3)C(C)=C([C@@H](O)C1=O)C2(C)C
InchiKey: ZDZOTLJHXYCWBA-AWAZFWMNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29846 BRD-K42125900 A375 10 uM 6 h 0.0 0.0 0.0 0.23 0.82 0.1
30437 BRD-K42125900 ASC 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
30744 BRD-K42125900 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31034 BRD-K42125900 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31341 BRD-K42125900 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.09 0.81
31644 BRD-K42125900 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31868 BRD-K42125900 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32420 BRD-K42125900 NPC 10 uM 24 h -0.2 -0.82 0.0 -0.32 -1.09 0.84
32635 BRD-K42125900 PC3 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.41 2.02
33019 BRD-K42125900 SKB 10 uM 24 h -0.24 -0.99 0.14 0.0 0.0 0.0
33283 BRD-K42125900 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96143 BRD-K42125900 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).