CMap Candidate Details

Structure:
CMap ID: C15824
Pert ID: BRD-K42191735
Compound Name: buparlisib
Targets: PIK3CA
MoA: PI3K inhibitor
SMILES: Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F
InchiKey: CWHUFRVAEUJCEF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91805 BRD-K42191735 HS578T 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.86 0.2
91991 BRD-K42191735 A375 1.11 uM 24 h 0.0 0.0 0.0 -0.5 -1.67 15.65
92019 BRD-K42191735 BT20 3.33 uM 24 h 0.26 1.08 0.21 -0.29 -0.99 0.5
92067 BRD-K42191735 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92099 BRD-K42191735 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.06
92215 BRD-K42191735 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92310 BRD-K42191735 MDAMB231 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92366 BRD-K42191735 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117060 BRD-K42191735 A549 1.11 uM 24 h 0.0 0.0 0.0 -0.43 -1.43 15.35
117187 BRD-K42191735 HEPG2 3.33 uM 24 h -0.22 -0.9 0.04 -0.36 -1.2 1.17
117305 BRD-K42191735 PC3 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.8
121700 BRD-K42191735 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.46 -1.56 15.65
129600 BRD-K42191735 HELA 2.22 uM 24 h 0.0 0.0 0.0 -0.43 -1.45 15.35
129630 BRD-K42191735 HT29 2.22 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
129659 BRD-K42191735 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 -0.39 -1.33 1.71
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).