CMap Candidate Details

Structure:
CMap ID: C15839
Pert ID: BRD-K42260897
Compound Name: ezetimibe
Targets: NPC1L1
MoA: Cholesterol inhibitor; Niemann-Pick C1-like 1 protein antagonist
SMILES: O[C@@H](CC[C@@H]1[C@H](N(C1=O)c1ccc(F)cc1)c1ccc(O)cc1)c1ccc(F)cc1
InchiKey: OLNTVTPDXPETLC-XPWALMASSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24438 BRD-K42260897 A375 10 uM 6 h 0.21 0.88 0.01 0.24 0.86 0.16
24578 BRD-K42260897 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24774 BRD-K42260897 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24905 BRD-K42260897 HT29 10 uM 6 h 0.0 0.0 0.0 0.31 1.1 0.68
25022 BRD-K42260897 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25246 BRD-K42260897 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25369 BRD-K42260897 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).