CMap Candidate Details

Structure:
CMap ID: C15870
Pert ID: BRD-K42417338
Compound Name: butorphanol-(+)-tartrate
Targets: OPRD1; OPRK1; OPRM1
MoA: Opioid receptor agonist; Opioid receptor antagonist
SMILES: Oc1ccc2C[C@H]3N(CC4CCC4)CC[C@@]4(CCCC[C@@]34O)c2c1
InchiKey: IFKLAQQSCNILHL-QHAWAJNXSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95469 BRD-K42417338 U2OS 10 uM 6 h -0.21 -0.89 0.03 0.0 0.0 0.0
123243 BRD-K42417338 A375 0.37 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.05
123318 BRD-K42417338 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123430 BRD-K42417338 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.65
123467 BRD-K42417338 THP1 10 uM 24 h 0.24 1.0 0.11 -0.29 -0.98 0.47
123500 BRD-K42417338 YAPC 0.04 uM 24 h 0.0 0.0 0.0 -0.44 -1.48 15.35
131557 BRD-K42417338 A549 2.22 uM 24 h -0.26 -1.1 0.33 0.0 0.0 0.0
131596 BRD-K42417338 HA1E 0.25 uM 24 h 0.28 1.16 0.36 0.0 0.0 0.0
131638 BRD-K42417338 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131689 BRD-K42417338 HT29 0.03 uM 24 h -0.22 -0.9 0.05 0.0 0.0 0.0
131737 BRD-K42417338 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
131791 BRD-K42417338 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
131830 BRD-K42417338 MCF10A 0.03 uM 24 h 0.2 0.85 0.01 0.25 0.88 0.19
131866 BRD-K42417338 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131899 BRD-K42417338 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).