CMap Candidate Details

Structure:
CMap ID: C15882
Pert ID: BRD-K42452249
Compound Name: EO-1428
Targets: MAPK14; MAPK11
MoA: P38 MAPK inhibitor
SMILES: Cc1ccccc1C(=O)c1ccc(Nc2ccc(Br)cc2N)cc1Cl
InchiKey: HDCLCHNAEZNGNV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3024 BRD-K42452249 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3367 BRD-K42452249 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3505 BRD-K42452249 PC3 10 uM 24 h 0.0 0.0 0.0 0.18 0.64 0.0
3799 BRD-K42452249 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41769 BRD-K42452249 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41934 BRD-K42452249 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42362 BRD-K42452249 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42687 BRD-K42452249 HEPG2 10 uM 6 h -0.3 -1.26 0.71 -0.26 -0.88 0.25
42989 BRD-K42452249 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43189 BRD-K42452249 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43552 BRD-K42452249 NPC 10 uM 24 h 0.26 1.09 0.23 0.0 0.0 0.0
43850 BRD-K42452249 PHH 10 uM 24 h 0.0 0.0 0.0 0.2 0.72 0.02
44116 BRD-K42452249 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99527 BRD-K42452249 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).