CMap Candidate Details

Structure:
CMap ID: C01590
Pert ID: BRD-A66155091
Compound Name: trilostane
Targets: ESR1; ESR2; HSD3B2
MoA: 3beta-hydroxy-delta5-steroid dehydrogenase inhibitor
SMILES: C[C@]12CC[C@@H]3[C@@H](CC[C@@]45O[C@@H]4C(=O)C(C[C@]35C)C#N)[C@@H]1CC[C@H]2O
InchiKey: RLQVKDVIBJCQGE-VWWPZJNLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124599 BRD-A66155091 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124619 BRD-A66155091 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
124639 BRD-A66155091 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124664 BRD-A66155091 HELA 10 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
124696 BRD-A66155091 HT29 0.04 uM 24 h -0.27 -1.11 0.36 0.22 0.79 0.08
124802 BRD-A66155091 MDAMB231 3.33 uM 24 h 0.36 1.52 1.44 0.0 0.0 0.0
124843 BRD-A66155091 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124884 BRD-A66155091 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124918 BRD-A66155091 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.26 0.94 0.28
132665 BRD-A66155091 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132838 BRD-A66155091 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
132875 BRD-A66155091 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132902 BRD-A66155091 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).