CMap Candidate Details

Structure:
CMap ID: C15904
Pert ID: BRD-K42500029
Compound Name: CGP-57380
Targets: MKNK1
MoA: MAP kinase inhibitor; MAPK-interacting kinase inhibitor
SMILES: Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
InchiKey: UQPMANVRZYYQMD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5330 BRD-K42500029 HA1E 10 uM 24 h 0.3 1.25 0.56 0.0 0.0 0.0
5630 BRD-K42500029 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5914 BRD-K42500029 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.87 0.23
6096 BRD-K42500029 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.29 1.04 0.56
6279 BRD-K42500029 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6548 BRD-K42500029 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37157 BRD-K42500029 A375 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.4
37657 BRD-K42500029 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38083 BRD-K42500029 HT29 10 uM 6 h 0.0 0.0 0.0 0.3 1.07 0.61
38482 BRD-K42500029 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38722 BRD-K42500029 PHH 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.84
38955 BRD-K42500029 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96144 BRD-K42500029 A549 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
99528 BRD-K42500029 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).