CMap Candidate Details

Structure:
CMap ID: C15976
Pert ID: BRD-K42728290
Compound Name: NVP-BGJ398
Targets: FGFR1; FGFR3; FGFR2; FGFR4
MoA: FGFR inhibitor
SMILES: CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
InchiKey: QADPYRIHXKWUSV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91806 BRD-K42728290 HS578T 10 uM 6 h 0.24 1.01 0.11 0.0 0.0 0.0
91870 BRD-K42728290 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91936 BRD-K42728290 SKBR3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92884 BRD-K42728290 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92911 BRD-K42728290 A549 0.12 uM 24 h -0.27 -1.14 0.42 -0.29 -0.99 0.5
92950 BRD-K42728290 ASC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93025 BRD-K42728290 CD34 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93058 BRD-K42728290 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93110 BRD-K42728290 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93148 BRD-K42728290 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93193 BRD-K42728290 HEPG2 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93251 BRD-K42728290 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93301 BRD-K42728290 JURKAT 3.33 uM 24 h 0.23 0.96 0.07 -0.27 -0.91 0.31
93336 BRD-K42728290 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
93379 BRD-K42728290 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.19 0.66 0.01
93408 BRD-K42728290 NPC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
93465 BRD-K42728290 PC3 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93524 BRD-K42728290 SKL 0.37 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
93564 BRD-K42728290 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93604 BRD-K42728290 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).