CMap Candidate Details

Structure:
CMap ID: C15984
Pert ID: BRD-K42748308
Compound Name: XE-991
Targets: KCNQ1; KCNQ2; KCNQ3
MoA: Potassium channel blocker
SMILES: O=C1c2ccccc2C(Cc2ccncc2)(Cc2ccncc2)c2ccccc12
InchiKey: KHJFBUUFMUBONL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5453 BRD-K42748308 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5774 BRD-K42748308 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5915 BRD-K42748308 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6098 BRD-K42748308 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.29 1.03 0.52
6189 BRD-K42748308 PC3 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
6416 BRD-K42748308 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37159 BRD-K42748308 A375 10 uM 6 h 0.32 1.32 0.78 0.0 0.0 0.0
37386 BRD-K42748308 A549 10 uM 6 h 0.0 0.0 0.0 0.27 0.97 0.35
37660 BRD-K42748308 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38084 BRD-K42748308 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38485 BRD-K42748308 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38724 BRD-K42748308 PHH 10 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.87
99533 BRD-K42748308 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).