CMap Candidate Details

Structure:
CMap ID: C01600
Pert ID: BRD-A66559694
Compound Name: naltrexone
Targets: OPRD1; OPRK1; OPRM1
MoA: Opioid receptor antagonist
SMILES: Oc1ccc2C[C@H]3N(CC4CC4)CCC45[C@@H](Oc1c24)C(=O)CC[C@@]35O
InchiKey: DQCKKXVULJGBQN-PODIIYFMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5274 BRD-A66559694 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
5540 BRD-A66559694 HCC515 10 uM 24 h -0.2 -0.84 0.0 -0.29 -0.96 0.44
6145 BRD-A66559694 PC3 10 uM 24 h -0.29 -1.21 0.58 0.0 0.0 0.0
6333 BRD-A66559694 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37094 BRD-A66559694 A375 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.59
37351 BRD-A66559694 A549 10 uM 6 h -0.22 -0.93 0.07 -0.32 -1.07 0.77
37533 BRD-A66559694 ASC 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
37841 BRD-A66559694 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38030 BRD-A66559694 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38161 BRD-A66559694 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38380 BRD-A66559694 NPC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
38653 BRD-A66559694 PHH 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
38879 BRD-A66559694 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97609 BRD-A66559694 NKDBA 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).