CMap Candidate Details

Structure:
CMap ID: C16003
Pert ID: BRD-K42828737
Compound Name: sunitinib
Targets: FLT1; FLT3; FLT4; KDR; KIT; PDGFRA; PDGFRB; RET
MoA: KIT inhibitor; FLT3 inhibitor; PDGFR inhibitor; VEGFR inhibitor; RET tyrosine kinase inhibitor
SMILES: CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2/C(=O)Nc3ccc(F)cc23)c1C
InchiKey: WINHZLLDWRZWRT-ATVHPVEESA-N
Compound Aliases: sunitinib-malate

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90773 BRD-K42828737 HPTEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92934 BRD-K42828737 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92997 BRD-K42828737 CD34 10 uM 24 h 0.31 1.3 0.7 0.0 0.0 0.0
93085 BRD-K42828737 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93128 BRD-K42828737 HELA 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.13
93223 BRD-K42828737 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93278 BRD-K42828737 JURKAT 0.04 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
93317 BRD-K42828737 MCF10A 10 uM 24 h -0.31 -1.29 0.79 -0.24 -0.82 0.15
93359 BRD-K42828737 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.3
93396 BRD-K42828737 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93487 BRD-K42828737 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93545 BRD-K42828737 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93585 BRD-K42828737 YAPC 10 uM 24 h 0.0 0.0 0.0 0.36 1.26 1.29
96755 BRD-K42828737 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116331 BRD-K42828737 A549 10 uM 24 h -0.24 -0.99 0.13 0.28 1.0 0.42
116372 BRD-K42828737 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116418 BRD-K42828737 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116470 BRD-K42828737 HEPG2 3.33 uM 24 h -0.28 -1.18 0.51 0.0 0.0 0.0
116520 BRD-K42828737 HT29 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.12
116568 BRD-K42828737 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116607 BRD-K42828737 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).