CMap Candidate Details

Structure:
CMap ID: C16064
Pert ID: BRD-K43002773
Compound Name: GDC-0068
Targets: AKT3; AKT1; AKT2
MoA: Akt inhibitor
SMILES: C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)C4=CC=C(C=C4)Cl)O
InchiKey: GRZXWCHAXNAUHY-NSISKUIASA-N
Compound Aliases: ipatasertib

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
493 BRD-K43002773 BJAB 10 uM 24 h 0.25 1.05 0.16 -0.25 -0.85 0.2
533 BRD-K43002773 HBL1 10 uM 24 h 0.27 1.14 0.32 -0.32 -1.06 0.74
597 BRD-K43002773 K562 10 uM 4 h 0.22 0.93 0.05 0.0 0.0 0.0
631 BRD-K43002773 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
676 BRD-K43002773 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
724 BRD-K43002773 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
758 BRD-K43002773 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
830 BRD-K43002773 OCILY3 10 uM 4 h 0.19 0.79 0.0 -0.27 -0.91 0.3
865 BRD-K43002773 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
962 BRD-K43002773 TMD8 10 uM 4 h 0.29 1.22 0.48 0.0 0.0 0.0
92863 BRD-K43002773 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92890 BRD-K43002773 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92955 BRD-K43002773 ASC 10 uM 24 h -0.3 -1.25 0.71 -0.39 -1.3 1.57
92983 BRD-K43002773 CD34 10 uM 24 h 0.28 1.19 0.41 -0.29 -0.97 0.46
93035 BRD-K43002773 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93073 BRD-K43002773 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93119 BRD-K43002773 HELA 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.58
93160 BRD-K43002773 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93209 BRD-K43002773 HUVEC 10 uM 24 h 0.34 1.4 1.02 -0.38 -1.27 1.43
93266 BRD-K43002773 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93307 BRD-K43002773 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.1
93349 BRD-K43002773 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93390 BRD-K43002773 NPC 10 uM 24 h -0.23 -0.97 0.11 -0.3 -1.03 0.62
93440 BRD-K43002773 PC3 1.11 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
93474 BRD-K43002773 SKL 10 uM 24 h -0.16 -0.67 0.0 0.0 0.0 0.0
93535 BRD-K43002773 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93576 BRD-K43002773 YAPC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).