CMap Candidate Details

Structure:
CMap ID: C01610
Pert ID: BRD-A67097164
Compound Name: ifosfamide
Targets: CYP2A6; CYP3A7; CYP2B6; CYP2C19; CYP2C8; CYP2C9; CYP2C18; CYP3A4; CYP3A5; PTGS1
MoA: DNA alkylating agent
SMILES: ClCCNP1(=O)OCCCN1CCCl
InchiKey: HOMGKSMUEGBAAB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91432 BRD-A67097164 HUH7 12.5 uM 72 h 0.0 0.0 0.0 -0.22 -0.74 0.05
124986 BRD-A67097164 A549 1.11 uM 24 h 0.0 0.0 0.0 0.41 1.46 2.23
125063 BRD-A67097164 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.68
125089 BRD-A67097164 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125141 BRD-A67097164 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.41 1.44 2.21
125189 BRD-A67097164 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132989 BRD-A67097164 A375 2.22 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.06
133025 BRD-A67097164 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133079 BRD-A67097164 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133105 BRD-A67097164 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133185 BRD-A67097164 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
133247 BRD-A67097164 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
133275 BRD-A67097164 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133329 BRD-A67097164 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).