CMap Candidate Details

Structure:
CMap ID: C01614
Pert ID: BRD-A67373739
Compound Name: AICA-ribonucleotide
Targets: PRKAA1
MoA: AMPK activator
SMILES: NC(=O)c1ncn(C2OC(COP(O)(O)=O)C(O)C2O)c1N
InchiKey: NOTGFIUVDGNKRI-UHFFFAOYSA-N
Compound Aliases: aica-ribonucleotide

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8882 BRD-A67373739 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9606 BRD-A67373739 H1299 10 uM 6 h 0.24 0.99 0.09 0.25 0.88 0.18
10182 BRD-A67373739 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10680 BRD-A67373739 HEPG2 10 uM 6 h -0.26 -1.1 0.33 -0.26 -0.89 0.26
10913 BRD-A67373739 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11354 BRD-A67373739 NCIH2073 10 uM 6 h 0.28 1.16 0.36 -0.19 -0.65 0.01
11664 BRD-A67373739 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11926 BRD-A67373739 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12216 BRD-A67373739 NOMO1 10 uM 6 h -0.27 -1.14 0.42 -0.21 -0.72 0.04
12678 BRD-A67373739 SW480 10 uM 6 h 0.0 0.0 0.0 0.29 1.03 0.5
13159 BRD-A67373739 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13544 BRD-A67373739 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123274 BRD-A67373739 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123285 BRD-A67373739 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123307 BRD-A67373739 HELA 1.11 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
123394 BRD-A67373739 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123416 BRD-A67373739 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.34
123452 BRD-A67373739 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131542 BRD-A67373739 A549 0.74 uM 24 h 0.17 0.73 0.0 -0.24 -0.82 0.15
131713 BRD-A67373739 HUVEC 0.08 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
131766 BRD-A67373739 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131816 BRD-A67373739 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.53
131846 BRD-A67373739 MCF??7.00 0.25 uM 24 h -0.31 -1.29 0.77 0.34 1.19 1.03
131948 BRD-A67373739 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.48
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).