CMap Candidate Details

Structure:
CMap ID: C16194
Pert ID: BRD-K43389675
Compound Name: daunorubicin
Targets: TOP2A
MoA: RNA synthesis inhibitor; Topoisomerase inhibitor
SMILES: COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
InchiKey: STQGQHZAVUOBTE-VGBVRHCVSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
989 BRD-K43389675 CD34 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1045 BRD-K43389675 HL60 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1109 BRD-K43389675 U937 0.37 uM 6 h 0.0 0.0 0.0 -0.37 -1.25 1.35
41937 BRD-K43389675 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42366 BRD-K43389675 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42690 BRD-K43389675 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43192 BRD-K43389675 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43854 BRD-K43389675 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44120 BRD-K43389675 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99539 BRD-K43389675 U2OS 3.33 uM 6 h -0.28 -1.15 0.44 0.31 1.09 0.67
115954 BRD-K43389675 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116031 BRD-K43389675 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116073 BRD-K43389675 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116162 BRD-K43389675 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116242 BRD-K43389675 PC3 0.04 uM 24 h 0.26 1.07 0.19 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).