CMap Candidate Details

Structure:
CMap ID: C16195
Pert ID: BRD-K43389698
Compound Name: BMS-387032
Targets: CDK2; CDK7; CDK9
MoA: CDK inhibitor; MCL1 inhibitor; Cell cycle inhibitor
SMILES: CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1
InchiKey: OUSFTKFNBAZUKL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92436 BRD-K43389698 A549 0.04 uM 24 h -0.21 -0.87 0.02 0.2 0.7 0.02
92466 BRD-K43389698 BT20 0.12 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
92501 BRD-K43389698 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92535 BRD-K43389698 HME1 0.12 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
92581 BRD-K43389698 HS578T 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92670 BRD-K43389698 LNCAP 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92736 BRD-K43389698 MCF10A 0.04 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92773 BRD-K43389698 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92827 BRD-K43389698 SKBR3 0.12 uM 24 h -0.25 -1.04 0.21 0.0 0.0 0.0
96859 BRD-K43389698 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97278 BRD-K43389698 HAP1 0.66 uM 24 h -0.27 -1.11 0.37 -0.27 -0.9 0.28
119667 BRD-K43389698 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119705 BRD-K43389698 HT29 0.125 uM 24 h 0.22 0.94 0.05 0.31 1.08 0.66
119753 BRD-K43389698 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119793 BRD-K43389698 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.38
119826 BRD-K43389698 PC3 0.125 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).