CMap Candidate Details

Structure:
CMap ID: C16222
Pert ID: BRD-K43457670
Compound Name: acetazolamide
Targets: CA14; CA2; CA4; CA7; CA12
MoA: Carbonic anhydrase inhibitor
SMILES: CC(=O)Nc1nnc(s1)S(N)(=O)=O
InchiKey: BZKPWHYZMXOIDC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
99541 BRD-K43457670 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123248 BRD-K43457670 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123434 BRD-K43457670 PC3 0.37 uM 24 h -0.24 -0.98 0.12 0.0 0.0 0.0
123505 BRD-K43457670 YAPC 0.04 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
131560 BRD-K43457670 A549 0.08 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.69
131600 BRD-K43457670 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131640 BRD-K43457670 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131669 BRD-K43457670 HELA 0.08 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
131690 BRD-K43457670 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.28
131742 BRD-K43457670 HUVEC 2.22 uM 24 h -0.29 -1.22 0.61 0.0 0.0 0.0
131796 BRD-K43457670 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131832 BRD-K43457670 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
131870 BRD-K43457670 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
131901 BRD-K43457670 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131939 BRD-K43457670 THP1 0.08 uM 24 h 0.26 1.07 0.2 -0.26 -0.89 0.26
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).