CMap Candidate Details

Structure:
CMap ID: C16261
Pert ID: BRD-K43578482
Compound Name: defactinib
Targets: PTK2
MoA: Focal adhesion kinase inhibitor
SMILES: CNC(=O)c1ccc(Nc2ncc(c(NCc3nccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
InchiKey: FWLMVFUGMHIOAA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123296 BRD-K43578482 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
123324 BRD-K43578482 HELA 3.33 uM 24 h -0.21 -0.86 0.02 0.22 0.77 0.05
123356 BRD-K43578482 HT29 3.33 uM 24 h -0.23 -0.95 0.09 0.26 0.91 0.23
123438 BRD-K43578482 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
123473 BRD-K43578482 THP1 3.33 uM 24 h -0.25 -1.04 0.21 -0.34 -1.16 1.11
123508 BRD-K43578482 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131535 BRD-K43578482 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131563 BRD-K43578482 A549 2.22 uM 24 h -0.24 -0.98 0.13 -0.24 -0.79 0.11
131602 BRD-K43578482 HA1E 2.22 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
131745 BRD-K43578482 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131800 BRD-K43578482 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
131833 BRD-K43578482 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131873 BRD-K43578482 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131905 BRD-K43578482 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).