CMap Candidate Details

Structure:
CMap ID: C16276
Pert ID: BRD-K43620258
Compound Name: CHEMBL-399379
Targets: ACLY
MoA: ATP citrase lyase inhibitor
SMILES: COc1ccc(cc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1O)-c1ccccc1
InchiKey: SIIPNDKXZOTLEA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9066 BRD-K43620258 A375 80 uM 6 h -0.24 -0.99 0.13 -0.39 -1.33 1.71
9204 BRD-K43620258 A549 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9426 BRD-K43620258 AGS 80 uM 6 h 0.24 1.0 0.11 -0.37 -1.25 1.35
9731 BRD-K43620258 H1299 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10373 BRD-K43620258 HCC515 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10518 BRD-K43620258 HCT116 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10975 BRD-K43620258 HT29 80 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11490 BRD-K43620258 NCIH2073 80 uM 6 h 0.0 0.0 0.0 -0.44 -1.48 15.35
11768 BRD-K43620258 NCIH508 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12054 BRD-K43620258 NCIH596 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12320 BRD-K43620258 NOMO1 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12606 BRD-K43620258 PC3 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12794 BRD-K43620258 SW480 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13275 BRD-K43620258 U937 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13622 BRD-K43620258 VCAP 80 uM 6 h 0.19 0.8 0.0 -0.3 -1.02 0.6
97663 BRD-K43620258 MCF??7.00 8 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97718 BRD-K43620258 NKDBA 8 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).