CMap Candidate Details

Structure:
CMap ID: C00163
Pert ID: BRD-A06352508
Compound Name: SB-218078
Targets: CHEK1
MoA: CHK inhibitor
SMILES: O=C1NC(=O)c2c1c1c3ccccc3n3C4CCC(O4)n4c5ccccc5c2c4c13
InchiKey: OTPNDVKVEAIXTI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5386 BRD-A06352508 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5818 BRD-A06352508 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.45
6312 BRD-A06352508 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
39259 BRD-A06352508 A549 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.33 1.71
39545 BRD-A06352508 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40678 BRD-A06352508 NEU 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
40971 BRD-A06352508 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41295 BRD-A06352508 SKB 10 uM 24 h 0.19 0.79 0.0 -0.34 -1.16 1.11
116287 BRD-A06352508 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116416 BRD-A06352508 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116518 BRD-A06352508 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.06
116566 BRD-A06352508 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116605 BRD-A06352508 PC3 3.33 uM 24 h 0.28 1.19 0.41 0.26 0.9 0.22
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).