CMap Candidate Details

Structure:
CMap ID: C16322
Pert ID: BRD-K43744935
Compound Name: tamoxifen
Targets: ESR1; ESR2
MoA: Estrogen receptor antagonist; Selective estrogen receptor modulator
SMILES: CCC(=C(c1ccccc1)c2ccc(OCCN(C)C)cc2)c3ccccc3
InchiKey: NKANXQFJJICGDU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4114 BRD-K43744935 HA1E 10 uM 24 h 0.23 0.98 0.09 0.3 1.07 0.63
4574 BRD-K43744935 HCC515 10 uM 6 h -0.28 -1.16 0.47 0.0 0.0 0.0
4806 BRD-K43744935 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4933 BRD-K43744935 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.68 0.02
37161 BRD-K43744935 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37290 BRD-K43744935 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37663 BRD-K43744935 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37906 BRD-K43744935 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38087 BRD-K43744935 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38205 BRD-K43744935 MCF??7.00 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
38488 BRD-K43744935 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38958 BRD-K43744935 SKB 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.2
99544 BRD-K43744935 U2OS 10 uM 6 h -0.26 -1.07 0.27 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).