CMap Candidate Details

Structure:
CMap ID: C01637
Pert ID: BRD-A68009927
Compound Name: daunorubicin
Targets: TOP2A
MoA: RNA synthesis inhibitor; Topoisomerase inhibitor
SMILES: COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](OC5CC(N)C(O)C(C)O5)c4c(O)c3C(=O)c12)C(C)=O
InchiKey: STQGQHZAVUOBTE-JYZNYWJRSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5006 BRD-A68009927 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
19877 BRD-A68009927 HCC515 10 uM 6 h 0.0 0.0 0.0 0.48 1.71 2.54
37536 BRD-A68009927 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38162 BRD-A68009927 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90552 BRD-A68009927 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119675 BRD-A68009927 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121831 BRD-A68009927 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129744 BRD-A68009927 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129776 BRD-A68009927 HA1E 0.01 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
129807 BRD-A68009927 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129862 BRD-A68009927 HELA 0.03 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
129889 BRD-A68009927 HT29 0.08 uM 24 h 0.0 0.0 0.0 -0.4 -1.34 1.85
129907 BRD-A68009927 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129933 BRD-A68009927 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.17
130018 BRD-A68009927 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130092 BRD-A68009927 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130144 BRD-A68009927 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).