CMap Candidate Details

Structure:
CMap ID: C16428
Pert ID: BRD-K44084986
Compound Name: Y-27632
Targets: ROCK1; ROCK2
MoA: Rho associated kinase inhibitor
SMILES: C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
InchiKey: IYOZTVGMEWJPKR-IJLUTSLNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6756 BRD-K44084986 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7157 BRD-K44084986 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7324 BRD-K44084986 HA1E 10 uM 24 h 0.29 1.22 0.48 0.0 0.0 0.0
7661 BRD-K44084986 HCC515 10 uM 6 h 0.0 0.0 0.0 0.27 0.96 0.34
7868 BRD-K44084986 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8282 BRD-K44084986 MCF??7.00 10 uM 6 h 0.26 1.09 0.22 0.29 1.02 0.47
8680 BRD-K44084986 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96919 BRD-K44084986 PC3 10 uM 24 h -0.21 -0.85 0.01 0.0 0.0 0.0
99547 BRD-K44084986 U2OS 20 uM 6 h 0.26 1.1 0.24 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).