CMap Candidate Details
Structure:
| CMap ID: | C16431 |
| Pert ID: | BRD-K44094599 |
| Compound Name: | tacrolimus |
| Targets: | FKBP1A |
| MoA: | Calcineurin inhibitor |
| SMILES: | CO[C@@H]1C[C@@H](CC[C@H]1O)C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)CC(C)=C/[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC |
| InchiKey: | QJJXYPPXXYFBGM-LJIGMGMYSA-N |
| Compound Aliases: | -- |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 24439 | BRD-K44094599 | A375 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 24672 | BRD-K44094599 | A549 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.37 | -1.24 | 1.31 |
| 24776 | BRD-K44094599 | HA1E | 10 uM | 6 h | -0.19 | -0.79 | 0.0 | -0.34 | -1.14 | 1.03 |
| 24907 | BRD-K44094599 | HT29 | 10 uM | 6 h | 0.18 | 0.75 | 0.0 | 0.28 | 1.0 | 0.42 |
| 25097 | BRD-K44094599 | MCF??7.00 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 25248 | BRD-K44094599 | PC3 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 25370 | BRD-K44094599 | VCAP | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |