CMap Candidate Details

Structure:
CMap ID: C16472
Pert ID: BRD-K44227013
Compound Name: ponatinib
Targets: FGFR1; FGFR3; FGFR2; FGFR4; FLT3; ABL1; KIT; RET; BCR; TEK
MoA: FLT3 inhibitor; PDGFR inhibitor; Abl kinase inhibitor
SMILES: CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
InchiKey: PHXJVRSECIGDHY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1163 BRD-K44227013 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1197 BRD-K44227013 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1268 BRD-K44227013 A549 0.12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1375 BRD-K44227013 U2OS 1.11 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
90880 BRD-K44227013 MCF10A 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
91807 BRD-K44227013 HS578T 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91892 BRD-K44227013 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.21
91961 BRD-K44227013 SKBR3 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.05 0.7
94409 BRD-K44227013 A375 3.33 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
94474 BRD-K44227013 ASC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94540 BRD-K44227013 CD34 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94590 BRD-K44227013 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94631 BRD-K44227013 HEK293 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
94682 BRD-K44227013 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94734 BRD-K44227013 HME1 10 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
94784 BRD-K44227013 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94827 BRD-K44227013 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.67
94880 BRD-K44227013 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95007 BRD-K44227013 NEU 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95050 BRD-K44227013 NPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95153 BRD-K44227013 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.12
95231 BRD-K44227013 SKL 10 uM 24 h 0.0 0.0 0.0 0.41 1.44 2.21
95264 BRD-K44227013 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).