CMap Candidate Details

Structure:
CMap ID: C01648
Pert ID: BRD-A68281735
Compound Name: REV-5901
Targets: ALOX5
MoA: Lipoxygenase inhibitor; Leukotriene receptor antagonist
SMILES: CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1
InchiKey: JRLOEMCOOZSCQP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2050 BRD-A68281735 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2648 BRD-A68281735 VCAP 10 uM 6 h 0.0 0.0 0.0 0.27 0.95 0.31
42229 BRD-A68281735 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42571 BRD-A68281735 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.82 0.14
43737 BRD-A68281735 PHH 10 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
44023 BRD-A68281735 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95520 BRD-A68281735 A549 10 uM 48 h 0.0 0.0 0.0 0.3 1.05 0.58
95611 BRD-A68281735 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96306 BRD-A68281735 A375 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
100290 BRD-A68281735 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
126666 BRD-A68281735 HA1E 0.12 uM 24 h 0.32 1.34 0.89 0.38 1.35 1.72
126761 BRD-A68281735 JURKAT 1.11 uM 24 h 0.22 0.93 0.05 0.31 1.1 0.7
126796 BRD-A68281735 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126871 BRD-A68281735 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126932 BRD-A68281735 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134754 BRD-A68281735 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134788 BRD-A68281735 HELA 0.01 uM 24 h 0.0 0.0 0.0 -0.2 -0.66 0.01
134816 BRD-A68281735 HT29 0.003 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.18
134847 BRD-A68281735 HUVEC 0.01 uM 24 h -0.22 -0.91 0.05 0.31 1.09 0.67
134955 BRD-A68281735 PC3 0.001 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134985 BRD-A68281735 YAPC 0.001 uM 24 h 0.24 1.01 0.11 0.19 0.67 0.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).