CMap Candidate Details

Structure:
CMap ID: C16510
Pert ID: BRD-K44353683
Compound Name: nateglinide
Targets: KCNJ11; ABCC8
MoA: Insulin secretagogue
SMILES: CC(C)[C@H]1CC[C@@H](CC1)C(=O)N[C@H](Cc1ccccc1)C(O)=O
InchiKey: OELFLUMRDSZNSF-BRWVUGGUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25510 BRD-K44353683 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90908 BRD-K44353683 HUH7 10 uM 72 h 0.17 0.72 0.0 -0.28 -0.95 0.41
123255 BRD-K44353683 A375 0.04 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
123378 BRD-K44353683 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123385 BRD-K44353683 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123443 BRD-K44353683 PC3 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
123476 BRD-K44353683 THP1 0.04 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
123512 BRD-K44353683 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131570 BRD-K44353683 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131605 BRD-K44353683 HA1E 0.08 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
131647 BRD-K44353683 HEK293 0.01 uM 24 h 0.24 1.02 0.13 0.24 0.86 0.16
131674 BRD-K44353683 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.49
131698 BRD-K44353683 HT29 2.22 uM 24 h 0.21 0.87 0.01 0.31 1.11 0.72
131751 BRD-K44353683 HUVEC 0.08 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
131807 BRD-K44353683 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131910 BRD-K44353683 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).