CMap Candidate Details

Structure:
CMap ID: C01654
Pert ID: BRD-A68464583
Compound Name: mazindol
Targets: SLC6A2; SLC6A3; SLC6A4
MoA: Dopamine reuptake inhibitor; Serotonin reuptake inhibitor
SMILES: OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1
InchiKey: ZPXSCAKFGYXMGA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126797 BRD-A68464583 MCF10A 3.33 uM 24 h -0.26 -1.06 0.26 -0.28 -0.95 0.4
126830 BRD-A68464583 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
126873 BRD-A68464583 MDAMB231 10 uM 24 h 0.22 0.9 0.03 0.0 0.0 0.0
126934 BRD-A68464583 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126983 BRD-A68464583 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134670 BRD-A68464583 A375 0.08 uM 24 h -0.26 -1.1 0.35 0.31 1.09 0.68
134693 BRD-A68464583 A549 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134720 BRD-A68464583 HA1E 0.01 uM 24 h -0.22 -0.92 0.06 0.26 0.94 0.28
134755 BRD-A68464583 HEK293 0.74 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
134789 BRD-A68464583 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134818 BRD-A68464583 HT29 0.03 uM 24 h -0.25 -1.02 0.19 -0.35 -1.19 1.15
134849 BRD-A68464583 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.92
134898 BRD-A68464583 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 -0.44 -1.48 15.35
134957 BRD-A68464583 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).