CMap Candidate Details

Structure:
CMap ID: C16667
Pert ID: BRD-K44827188
Compound Name: vismodegib
Targets: SMO
MoA: Hedgehog pathway inhibitor; Smoothened receptor antagonist
SMILES: Clc1cc(ccc1C(=O)Nc1ccc(Cl)c(c1)-c1ccccn1)S(C)(=O)=O
InchiKey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96452 BRD-K44827188 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118804 BRD-K44827188 HCC515 1.11 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
118846 BRD-K44827188 HEPG2 3.33 uM 24 h -0.32 -1.31 0.82 0.0 0.0 0.0
118959 BRD-K44827188 PC3 0.12 uM 24 h -0.29 -1.21 0.6 0.32 1.12 0.76
124607 BRD-K44827188 HA1E 10 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.28
124680 BRD-K44827188 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124715 BRD-K44827188 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124752 BRD-K44827188 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124781 BRD-K44827188 MDAMB231 0.37 uM 24 h -0.22 -0.9 0.04 -0.31 -1.06 0.72
132679 BRD-K44827188 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132740 BRD-K44827188 HEK293 0.03 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.27
132781 BRD-K44827188 HELA 2.22 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
132858 BRD-K44827188 MCF10A 0.25 uM 24 h -0.26 -1.09 0.31 0.0 0.0 0.0
132924 BRD-K44827188 THP1 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132943 BRD-K44827188 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).