CMap Candidate Details

Structure:
CMap ID: C16723
Pert ID: BRD-K44974079
Compound Name: ticagrelor
Targets: P2RY12
MoA: Purinergic receptor antagonist
SMILES: CCCSc1nc(N[C@@H]2C[C@@H]2c2ccc(F)c(F)c2)c2nnn([C@@H]3C[C@H](OCCO)[C@H](O)[C@H]3O)c2n1
InchiKey: OEKWJQXRCDYSHL-MGXMICMRSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125268 BRD-K44974079 HA1E 0.04 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
125290 BRD-K44974079 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125365 BRD-K44974079 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125387 BRD-K44974079 JURKAT 0.125 uM 24 h -0.34 -1.42 1.43 0.0 0.0 0.0
125426 BRD-K44974079 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125469 BRD-K44974079 MDAMB231 10 uM 24 h -0.21 -0.88 0.03 0.29 1.01 0.45
125481 BRD-K44974079 PC3 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
125510 BRD-K44974079 THP1 10 uM 24 h -0.21 -0.85 0.01 0.0 0.0 0.0
133330 BRD-K44974079 A375 0.08 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
133352 BRD-K44974079 A549 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133408 BRD-K44974079 HELA 2.22 uM 24 h 0.25 1.02 0.13 -0.27 -0.92 0.33
133501 BRD-K44974079 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133618 BRD-K44974079 YAPC 0.01 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.36
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).