CMap Candidate Details

Structure:
CMap ID: C01674
Pert ID: BRD-A68930007
Compound Name: ouabain
Targets: ATP1A1
MoA: ATPase inhibitor
SMILES: C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)C4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C2=CC(=O)OC2)[C@H](O)[C@H](O)[C@H]1O
InchiKey: LPMXVESGRSUGHW-XPXORLBYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5277 BRD-A68930007 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
5543 BRD-A68930007 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6148 BRD-A68930007 PC3 10 uM 24 h 0.0 0.0 0.0 -0.46 -1.55 15.35
6482 BRD-A68930007 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37096 BRD-A68930007 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37352 BRD-A68930007 A549 10 uM 6 h 0.0 0.0 0.0 -0.63 -2.13 15.65
37538 BRD-A68930007 ASC 10 uM 24 h 0.25 1.05 0.16 -0.33 -1.13 0.97
37844 BRD-A68930007 HEPG2 10 uM 6 h -0.23 -0.95 0.09 -0.47 -1.58 15.65
38033 BRD-A68930007 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38163 BRD-A68930007 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 1.86
38383 BRD-A68930007 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38654 BRD-A68930007 PHH 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
38881 BRD-A68930007 SKB 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).