CMap Candidate Details

Structure:
CMap ID: C01675
Pert ID: BRD-A68942014
Compound Name: amitifadine
Targets: SLC6A2; SLC6A3; SLC6A4
MoA: SERT inhibitor
SMILES: Clc1ccc(cc1Cl)C12CC1CNC2
InchiKey: BSMNRYCSBFHEMQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96675 BRD-A68942014 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126625 BRD-A68942014 A375 0.37 uM 24 h -0.25 -1.04 0.21 0.0 0.0 0.0
126669 BRD-A68942014 HA1E 1.11 uM 24 h 0.3 1.24 0.52 -0.2 -0.69 0.02
126766 BRD-A68942014 JURKAT 10 uM 24 h -0.2 -0.84 0.01 -0.2 -0.68 0.02
126833 BRD-A68942014 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
126876 BRD-A68942014 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126938 BRD-A68942014 THP1 0.04 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
134695 BRD-A68942014 A549 0.25 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.4
134758 BRD-A68942014 HEK293 0.01 uM 24 h 0.0 0.0 0.0 -0.41 -1.37 2.02
134791 BRD-A68942014 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134820 BRD-A68942014 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134853 BRD-A68942014 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134920 BRD-A68942014 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134987 BRD-A68942014 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).