CMap Candidate Details

Structure:
CMap ID: C16761
Pert ID: BRD-K45071273
Compound Name: tetracaine
Targets: SCN9A; SCN10A
MoA: Membrane integrity inhibitor
SMILES: CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InchiKey: GKCBAIGFKIBETG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
114791 BRD-K45071273 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
125584 BRD-K45071273 A375 1.11 uM 24 h 0.2 0.84 0.0 0.24 0.86 0.16
125696 BRD-K45071273 HT29 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
125736 BRD-K45071273 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125852 BRD-K45071273 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
125934 BRD-K45071273 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133669 BRD-K45071273 A549 0.74 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
133700 BRD-K45071273 HA1E 0.01 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
133732 BRD-K45071273 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133768 BRD-K45071273 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133826 BRD-K45071273 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133858 BRD-K45071273 MCF10A 0.74 uM 24 h -0.28 -1.19 0.51 0.0 0.0 0.0
133884 BRD-K45071273 MCF??7.00 0.03 uM 24 h 0.28 1.18 0.39 -0.27 -0.91 0.3
133944 BRD-K45071273 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.05
133980 BRD-K45071273 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).