CMap Candidate Details

Structure:
CMap ID: C16779
Pert ID: BRD-K45117373
Compound Name: Y-26763
Targets: KCNJ8
MoA: Potassium channel activator
SMILES: CC(=O)N(O)[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C#N
InchiKey: IWTCFIIOUXJOOV-OLZOCXBDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5635 BRD-K45117373 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5917 BRD-K45117373 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.23 0.82 0.1
6418 BRD-K45117373 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.46 -1.54 15.35
37162 BRD-K45117373 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37665 BRD-K45117373 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38490 BRD-K45117373 NPC 10 uM 24 h 0.22 0.92 0.04 -0.25 -0.83 0.16
38728 BRD-K45117373 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38959 BRD-K45117373 SKB 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.46
99556 BRD-K45117373 U2OS 10 uM 6 h -0.28 -1.16 0.46 -0.26 -0.86 0.21
125652 BRD-K45117373 HEK293 10 uM 24 h 0.17 0.69 0.0 -0.24 -0.82 0.15
125733 BRD-K45117373 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125777 BRD-K45117373 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.36
125849 BRD-K45117373 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.02
125931 BRD-K45117373 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133666 BRD-K45117373 A549 0.74 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
133698 BRD-K45117373 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
133765 BRD-K45117373 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133798 BRD-K45117373 HT29 0.74 uM 24 h 0.21 0.87 0.01 -0.28 -0.94 0.37
133856 BRD-K45117373 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133882 BRD-K45117373 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133943 BRD-K45117373 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133979 BRD-K45117373 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).