CMap Candidate Details

Structure:
CMap ID: C16794
Pert ID: BRD-K45168550
Compound Name: SB-756050
Targets: GPBAR1
MoA: G protein-coupled receptor agonist
SMILES: COc1ccc(cc1OC)S(=O)(=O)N1CCCN(CC1)S(=O)(=O)c1ccc(OC)c(OC)c1
InchiKey: GJUFPAZNBPFNRI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125273 BRD-K45168550 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.24
125297 BRD-K45168550 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125349 BRD-K45168550 HELA 10 uM 24 h -0.26 -1.07 0.27 0.32 1.13 0.81
125392 BRD-K45168550 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
125414 BRD-K45168550 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125433 BRD-K45168550 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125486 BRD-K45168550 PC3 10 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
125543 BRD-K45168550 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133331 BRD-K45168550 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133356 BRD-K45168550 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133444 BRD-K45168550 HT29 2.22 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.09
133542 BRD-K45168550 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133597 BRD-K45168550 THP1 0.25 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).