CMap Candidate Details

Structure:
CMap ID: C16879
Pert ID: BRD-K45401373
Compound Name: betulinic-acid
Targets: GPBAR1
MoA: Apoptosis stimulant; Caspase activator; NFkB pathway activator; HIV integrase inhibitor; Topoisomerase inhibitor; Diacylglycerol O acyltransferase inhibitor; SARS coronavirus 3C-like protease inhibitor
SMILES: CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(O)=O
InchiKey: QGJZLNKBHJESQX-FZFNOLFKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3207 BRD-K45401373 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3805 BRD-K45401373 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39701 BRD-K45401373 ASC 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.21
40817 BRD-K45401373 NEU 10 uM 24 h -0.3 -1.24 0.65 0.22 0.79 0.07
41121 BRD-K45401373 NPC 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
41456 BRD-K45401373 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115644 BRD-K45401373 A375 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
115681 BRD-K45401373 A549 10 uM 24 h -0.29 -1.19 0.53 -0.24 -0.82 0.15
115720 BRD-K45401373 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115806 BRD-K45401373 HEPG2 10 uM 24 h -0.22 -0.94 0.07 -0.37 -1.26 1.36
115853 BRD-K45401373 HT29 0.37 uM 24 h -0.31 -1.3 0.81 0.0 0.0 0.0
115891 BRD-K45401373 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115931 BRD-K45401373 PC3 10 uM 24 h -0.18 -0.75 0.0 0.23 0.82 0.1
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).