CMap Candidate Details

Structure:
CMap ID: C01694
Pert ID: BRD-A69636825
Compound Name: diltiazem
Targets: CACNA1C
MoA: Calcium channel blocker
SMILES: COc1ccc(cc1)C1Sc2ccccc2N(CCN(C)C)C(=O)C1OC(C)=O
InchiKey: HSUGRBWQSSZJOP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5733 BRD-A69636825 HCC515 10 uM 6 h 0.0 0.0 0.0 0.26 0.91 0.23
5855 BRD-A69636825 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6483 BRD-A69636825 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.65
37539 BRD-A69636825 ASC 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
38384 BRD-A69636825 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38655 BRD-A69636825 PHH 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
100295 BRD-A69636825 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
126359 BRD-A69636825 A375 0.125 uM 24 h 0.0 0.0 0.0 0.19 0.69 0.01
126376 BRD-A69636825 A549 10 uM 24 h 0.17 0.73 0.0 0.0 0.0 0.0
126428 BRD-A69636825 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
126470 BRD-A69636825 HELA 0.125 uM 24 h -0.24 -1.0 0.14 0.31 1.11 0.74
126534 BRD-A69636825 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
126550 BRD-A69636825 MDAMB231 10 uM 24 h 0.25 1.03 0.13 -0.32 -1.07 0.75
126575 BRD-A69636825 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.58
126595 BRD-A69636825 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134394 BRD-A69636825 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134457 BRD-A69636825 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134494 BRD-A69636825 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
134535 BRD-A69636825 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.39
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).