CMap Candidate Details

Structure:
CMap ID: C01699
Pert ID: BRD-A69815203
Compound Name: cyclosporin-a
Targets: PPIA; PPP3CA
MoA: Calcineurin inhibitor
SMILES: CCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InchiKey: PMATZTZNYRCHOR-IMVLJIQESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5278 BRD-A69815203 HA1E 10 uM 24 h 0.25 1.03 0.14 0.0 0.0 0.0
5734 BRD-A69815203 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5856 BRD-A69815203 HEPG2 10 uM 6 h -0.24 -1.01 0.16 -0.27 -0.91 0.31
6484 BRD-A69815203 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39586 BRD-A69815203 ASC 10 uM 24 h 0.18 0.74 0.0 0.34 1.22 1.15
40710 BRD-A69815203 NEU 10 uM 24 h 0.16 0.68 0.0 -0.42 -1.43 15.35
41010 BRD-A69815203 NPC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
41333 BRD-A69815203 SKB 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.2
90635 BRD-A69815203 HCT116 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98077 BRD-A69815203 P1A82 10 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
100298 BRD-A69815203 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
126387 BRD-A69815203 A549 10 uM 24 h -0.3 -1.24 0.64 0.0 0.0 0.0
126454 BRD-A69815203 HEK293 3.33 uM 24 h -0.26 -1.08 0.3 0.0 0.0 0.0
126483 BRD-A69815203 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126614 BRD-A69815203 YAPC 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.21
134358 BRD-A69815203 A375 2.22 uM 24 h 0.19 0.78 0.0 0.0 0.0 0.0
134474 BRD-A69815203 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.6
134521 BRD-A69815203 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.64
134546 BRD-A69815203 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134576 BRD-A69815203 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134609 BRD-A69815203 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134633 BRD-A69815203 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).