CMap Candidate Details

Structure:
CMap ID: C01705
Pert ID: BRD-A69960130
Compound Name: bromocriptine
Targets: ADRA2A; ADRA2B; ADRA2C; DRD1; DRD2; DRD3; DRD4; DRD5; HTR1A; HTR1B; HTR1D; HTR2A; HTR2B; HTR2C
MoA: Dopamine receptor agonist
SMILES: CC(C)CC1N2C(=O)C(NC(=O)C3CN(C)C4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(OC2(O)C7CCCN7C1=O)C(C)C
InchiKey: OZVBMTJYIDMWIL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2817 BRD-A69960130 HA1E 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
3116 BRD-A69960130 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3450 BRD-A69960130 PC3 10 uM 24 h -0.17 -0.73 0.0 0.0 0.0 0.0
3698 BRD-A69960130 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39062 BRD-A69960130 A375 10 uM 6 h -0.19 -0.78 0.0 0.0 0.0 0.0
39406 BRD-A69960130 A549 10 uM 6 h 0.0 0.0 0.0 0.31 1.11 0.74
39587 BRD-A69960130 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39908 BRD-A69960130 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40193 BRD-A69960130 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40434 BRD-A69960130 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40711 BRD-A69960130 NEU 10 uM 24 h 0.25 1.05 0.16 -0.28 -0.95 0.4
41011 BRD-A69960130 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41334 BRD-A69960130 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).