CMap Candidate Details

Structure:
CMap ID: C17056
Pert ID: BRD-K45924332
Compound Name: amrinone
Targets: PDE3A
MoA: Phosphodiesterase inhibitor
SMILES: Nc1cc(c[nH]c1=O)-c1ccncc1
InchiKey: RNLQIBCLLYYYFJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125589 BRD-K45924332 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125676 BRD-K45924332 HELA 10 uM 24 h 0.24 0.99 0.1 -0.28 -0.94 0.38
125742 BRD-K45924332 HUVEC 3.33 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
125782 BRD-K45924332 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125940 BRD-K45924332 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133670 BRD-K45924332 A549 0.25 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.78
133705 BRD-K45924332 HA1E 0.03 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
133736 BRD-K45924332 HEK293 0.74 uM 24 h 0.0 0.0 0.0 -0.44 -1.49 15.35
133802 BRD-K45924332 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133863 BRD-K45924332 MCF10A 0.08 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
133887 BRD-K45924332 MCF??7.00 2.22 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
133918 BRD-K45924332 MDAMB231 0.03 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
133948 BRD-K45924332 PC3 0.74 uM 24 h 0.28 1.16 0.35 0.0 0.0 0.0
133982 BRD-K45924332 THP1 0.25 uM 24 h -0.26 -1.1 0.33 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).