CMap Candidate Details

Structure:
CMap ID: C17094
Pert ID: BRD-K46018455
Compound Name: bezafibrate
Targets: PPARA; PPARD; PPARG
MoA: PPAR receptor agonist
SMILES: CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O
InchiKey: IIBYAHWJQTYFKB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4434 BRD-K46018455 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5088 BRD-K46018455 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37670 BRD-K46018455 ASC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
37910 BRD-K46018455 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38733 BRD-K46018455 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38962 BRD-K46018455 SKB 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
90991 BRD-K46018455 HUH7 10 uM 72 h 0.0 0.0 0.0 -0.22 -0.75 0.06
98901 BRD-K46018455 NEU 10 uM 24 h -0.21 -0.89 0.03 0.26 0.92 0.24
99152 BRD-K46018455 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99564 BRD-K46018455 U2OS 15 uM 6 h -0.24 -1.0 0.15 0.0 0.0 0.0
125587 BRD-K46018455 A375 10 uM 24 h 0.25 1.04 0.14 0.28 1.01 0.44
125616 BRD-K46018455 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125698 BRD-K46018455 HT29 0.37 uM 24 h 0.3 1.26 0.56 0.0 0.0 0.0
125739 BRD-K46018455 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
125780 BRD-K46018455 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125830 BRD-K46018455 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125877 BRD-K46018455 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125896 BRD-K46018455 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125937 BRD-K46018455 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133703 BRD-K46018455 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
133734 BRD-K46018455 HEK293 0.25 uM 24 h -0.28 -1.18 0.51 0.0 0.0 0.0
133771 BRD-K46018455 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133861 BRD-K46018455 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133916 BRD-K46018455 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).