CMap Candidate Details

Structure:
CMap ID: C17100
Pert ID: BRD-K46056750
Compound Name: AZD-7762
Targets: CHEK1; CHEK2
MoA: CHK inhibitor
SMILES: NC(=O)Nc1cc(sc1C(=O)N[C@@H]1CCCNC1)-c1cccc(F)c1
InchiKey: IAYGCINLNONXHY-GFCCVEGCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
30065 BRD-K46056750 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30447 BRD-K46056750 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
31044 BRD-K46056750 HCC515 10 uM 6 h -0.2 -0.83 0.0 0.0 0.0 0.0
31351 BRD-K46056750 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32181 BRD-K46056750 NEU 10 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
32430 BRD-K46056750 NPC 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
32778 BRD-K46056750 PC3 10 uM 6 h 0.0 0.0 0.0 0.35 1.23 1.2
33029 BRD-K46056750 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33289 BRD-K46056750 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91545 BRD-K46056750 BT20 10 uM 6 h 0.0 0.0 0.0 0.3 1.08 0.65
91652 BRD-K46056750 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91709 BRD-K46056750 MDAMB231 10 uM 6 h 0.0 0.0 0.0 0.4 1.41 2.19
91772 BRD-K46056750 SKBR3 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92415 BRD-K46056750 A375 0.04 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
92508 BRD-K46056750 HA1E 0.12 uM 24 h -0.21 -0.87 0.02 -0.37 -1.24 1.31
92564 BRD-K46056750 HME1 3.33 uM 3 h 0.0 0.0 0.0 0.31 1.11 0.72
92589 BRD-K46056750 HS578T 0.04 uM 24 h 0.28 1.16 0.36 0.0 0.0 0.0
92636 BRD-K46056750 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92680 BRD-K46056750 LNCAP 0.37 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
92744 BRD-K46056750 MCF10A 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).